Central Line Dressing Change, , Central lines are at a high risk of serious infection. Proper central line care is a key to preventing these central line associated bloodstream infections called How often should the dressing on a peripherally inserted central catheter ( PICC) be changed in an adult, and should the interval be shorter for immunocompromised patients, those with prior catheterrelated infection, or PICC Line Together by St. Jude About Your Peripherally Inserted Central Catheter (PICC) Memorial Sloan Kettering Cancer Center